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chronic), differences in the animal species used, as well as the particular biological or physiological end-points being measured (through a pharmacodynamic mechanism).Furthermore, the ratio between the two phytocannabinoids also appears to play a role in determining whether the overall effect will be of a potentiating or antagonistic nature. In one study, 24 healthy men and women who had reported using cannabis at least 10 times in their lifetime were subjected to a double-blind, placebo-controlled, mixed between- and within-subject clinical trial that showed that deliberate systematic variations in the levels of either .and animal studies point to potential therapeutic indications such as psychosis, epilepsy, anxiety, sleep disturbances, neurodegeneration, cerebral and myocardial ischemia, inflammation, pain and immune responses, emesis, food intake, type-1 diabetes, liver disease, osteogenesis, and cancer (reviewed in used in the different studies, differences in the routes of administration, dose ordering effects (CBD pretreatment vs.simultaneous co-administration), differences in the duration or chronicity of treatment (acute vs.The study reported that in a population of over 5,000 Dutch patients using cannabis for medical purposes, the average daily dose of dried cannabis (various potencies) used was 0.68 grams per day (range: 0.65 - 0.82 grams per day) (Hazekamp and Heerdink 2013). However, cannabis and cannabinoids should not be considered equivalent even though the information on both is presented together within the text.In addition, information from Israel's medical marihuana program suggests that the average daily amount used by patients was approximately 1.5 grams of dried cannabis per day in 2011-2012 (Health Canada personal communication). Cannabis is a highly complex material with hundreds of chemical constituents whereas cannabinoids are single molecules.anti-oxidant, anti-anxiety, anti-inflammatory, anti-bacterial, anti-neoplastic, anti-malarial), but this information comes from a few studies and no clinical trials exist to support these claims.Terpenes vary widely among cannabis varieties and are thought to be primarily responsible for differences in fragrance among the different .
Furthermore, pyrolysis transforms each of the hundreds of compounds in cannabis into a number of other compounds, many of which remain to be characterized both chemically and pharmacologically.This document has been prepared by the Controlled Substances and Tobacco Directorate at Health Canada to provide information on the use of cannabis and cannabinoids for medical purposes.Cannabis is not an approved therapeutic product and the provision of this information should not be interpreted as an endorsement of the use of this product, or cannabis generally, by Health Canada.It is not meant to be comprehensive and should be used as a complement to other reliable sources of information.Following the most recent update to this document (February 2013), a study was published in the Netherlands tracking data obtained from the Dutch medical cannabis program over the years 2003-2010. Clinical Director, Schizophrenia Program Endowed Chair in Addiction Psychiatry, University of Toronto Centre for Addiction and Mental Health 250 College Street, Suite 734 Toronto, ON M5T 1R8 Canada IMPORTANT NOTE: For the sake of completeness and for contextual purposes, the content in the following document includes information on dried cannabis as well as selected cannabinoids.